| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Children of Men (2006) | £1,284,254 | £1,284,254 | £1,284,254 | new | 1 |
| 2 (2) |  | The Queen (2006) | £908,295 | £1,802,250 | £2,658,523 | 6% | 2 |
| 3 (1) |  | Talladega Nights: The Ballad of Ricky Bobby (2006) | £679,775 | £1,248,054 | £2,281,813 | -34% | 2 |
| 4 (5) |  | Little Man (2006) | £457,695 | £626,084 | £3,684,673 | -18% | 4 |
| 5 (4) |  | You, Me and Dupree (2006) | £430,309 | £703,382 | £7,495,391 | -24% | 5 |
| 6 (6) |  | Little Miss Sunshine (2006) | £369,153 | £637,231 | £1,666,968 | -6% | 3 |
| 7 (3) |  | The Black Dahlia (2006) | £334,895 | £677,096 | £1,243,970 | -41% | 2 |
| 8 (new) |  | Trust the Man (2006) | £280,929 | £280,929 | £280,929 | new | 1 |
| 9 (new) |  | Dirty Sanchez: The Movie (2006) | £257,034 | £257,034 | £257,034 | new | 1 |
| 10 (new) |  | Clerks II (2006) | £223,046 | £223,046 | £223,046 | new | 1 |
| 11 (11) |  | Monster House (2006) | £125,428 | £142,839 | £6,348,539 | -25% | 7 |
| 12 (re) |  | An Inconvenient Truth (2006) | £121,340 | £121,340 | £242,444 | re | 1 |
| 13 (7) |  | The Night Listener (2006) | £120,430 | £301,993 | £616,071 | -62% | 2 |
| 14 (13) |  | Cars (2006) | £104,582 | £122,493 | £16,099,943 | -31% | 9 |
| 15 (12) |  | Volver (2006) | £98,128 | £215,565 | £2,301,963 | -40% | 5 |