| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Casino Royale (2006) | £8,546,238 | £14,562,831 | £27,933,800 | -36% | 2 |
| 2 (2) |  | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan (2006) | £1,470,923 | £2,533,479 | £21,234,408 | -42% | 4 |
| 3 (new) |  | The Santa Clause 3: The Escape Clause (2006) | £1,274,774 | £1,274,774 | £1,274,774 | new | 1 |
| 4 (new) |  | Tenacious D In the Pick of Destiny (2006) | £922,574 | £922,574 | £922,574 | new | 1 |
| 5 (new) |  | Jackass Number Two (2006) | £735,274 | £735,274 | £735,274 | new | 1 |
| 6 (new) |  | Dhoom 2 (2006) | £415,701 | £415,701 | £415,701 | new | 1 |
| 7 (3) |  | The Prestige (2006) | £327,984 | £620,937 | £2,903,323 | -43% | 3 |
| 8 (new) |  | Pans Labyrinth (2006) | £298,432 | £298,432 | £298,432 | new | 1 |
| 9 (4) |  | Step Up (2006) | £166,146 | £288,601 | £4,282,719 | -59% | 5 |
| 10 (5) |  | Saw III (2006) | £109,339 | £284,709 | £8,458,236 | -73% | 5 |
| 11 (6) |  | Barnyard (2006) | £84,089 | £110,971 | £4,477,314 | -69% | 6 |
| 12 (new) |  | Hollywoodland (2006) | £65,735 | £65,735 | £65,735 | new | 1 |
| 13 (7) |  | Open Season (2006) | £56,287 | £77,830 | £7,418,065 | -78% | 7 |
| 14 (8) |  | The Departed (2006) | £50,300 | £133,928 | £12,576,260 | -68% | 8 |
| 15 (11) |  | Starter For 10 (2006) | £40,311 | £103,385 | £524,558 | -64% | 3 |