| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar (2009) | £4,865,081 | £7,629,476 | £65,070,599 | -6% | 7 |
| 2 (3) |  | Alvin and the Chipmunks: The Squeakquel (2009) | £1,195,220 | £1,389,971 | £19,953,194 | -18% | 6 |
| 3 (new) |  | Edge of Darkness (2010) | £1,172,927 | £1,172,927 | £1,172,927 | new | 1 |
| 4 (2) |  | Sherlock Holmes (2009) | £1,149,268 | £1,805,598 | £23,178,097 | -30% | 6 |
| 5 (5) |  | Its Complicated (2009) | £849,416 | £1,695,668 | £7,093,321 | -26% | 4 |
| 6 (4) |  | Up In the Air (2009) | £735,463 | £1,352,559 | £4,635,071 | -39% | 3 |
| 7 (6) |  | Toy Story 2 (1999) | £690,291 | £923,292 | £45,323,406 | -24% | 14 |
| 8 (7) |  | The Book of Eli (2010) | £484,983 | £885,822 | £3,521,900 | -41% | 3 |
| 9 (new) |  | Precious: Based On the Novel Push By Sapphire (2009) | £260,921 | £260,921 | £260,921 | new | 1 |
| 10 (8) |  | Daybreakers (2009) | £238,840 | £442,631 | £3,964,589 | -43% | 4 |
| 11 (9) |  | Brother's (2010) | £209,439 | £429,455 | £795,745 | -43% | 2 |
| 12 (10) | | A Prophet (2010) | £203,003 | £377,086 | £689,323 | -35% | 2 |
| 13 (11) |  | The Road (2010) | £168,513 | £319,919 | £2,324,269 | -34% | 4 |
| 14 (13) |  | St. Trinian's 2: The Legend of Frittons Gold (2009) | £136,169 | £154,144 | £6,942,986 | -31% | 7 |
| 15 (12) |  | Did You Hear About the Morgans? (2010) | £123,791 | £213,894 | £3,553,569 | -38% | 5 |