| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar (2009) | £4,865,081 | £7,629,476 | £65,070,599 | -6% | 7 |
| 2 (3) |  | Alvin and the Chipmunks: The Squeakquel (2009) | £1,195,220 | £1,389,971 | £19,953,194 | -18% | 6 |
| 3 (new) |  | Edge of Darkness (2010) | £1,172,927 | £1,172,927 | £1,172,927 | new | 1 |
| 4 (2) |  | Sherlock Holmes (2009) | £1,149,268 | £1,805,598 | £23,178,097 | -30% | 6 |
| 5 (5) |  | Its Complicated (2009) | £849,416 | £1,695,668 | £7,093,321 | -26% | 4 |
| 6 (4) |  | Up In the Air (2009) | £735,463 | £1,352,559 | £4,635,071 | -39% | 3 |
| 7 (6) |  | Toy Story 2 (1999) | £690,291 | £923,292 | £45,323,406 | -24% | 14 |
| 8 (7) |  | The Book of Eli (2010) | £484,983 | £885,822 | £3,521,900 | -41% | 3 |
| 9 (new) |  | Precious: Based On the Novel Push By Sapphire (2009) | £260,921 | £260,921 | £260,921 | new | 1 |
| 10 (8) |  | Daybreakers (2009) | £238,840 | £442,631 | £3,964,589 | -43% | 4 |
| 11 (9) |  | Brother's (2010) | £209,439 | £429,455 | £795,745 | -43% | 2 |
| 12 (10) | | A Prophet (2010) | £203,003 | £377,086 | £689,323 | -35% | 2 |
| 13 (11) |  | The Road (2010) | £168,513 | £319,919 | £2,324,269 | -34% | 4 |
| 14 (13) |  | St. Trinian's 2: The Legend of Frittons Gold (2009) | £136,169 | £154,144 | £6,942,986 | -31% | 7 |
| 15 (12) |  | Did You Hear About the Morgans? (2010) | £123,791 | £213,894 | £3,553,569 | -38% | 5 |
| 16 (21) |  | Sex & Drugs & Rock & Roll (2010) | £64,342 | £97,411 | £663,012 | 5% | 4 |
| 17 (16) |  | Planet 51 (2009) | £55,104 | £57,562 | £4,668,897 | -31% | 9 |
| 18 (new) |  | Rann (2010) | £44,544 | £44,544 | £44,544 | new | 1 |
| 19 (17) |  | Nine (2009) | £41,939 | £96,823 | £3,097,430 | -46% | 7 |
| 20 (23) |  | An Education (2009) | £33,933 | £54,990 | £2,090,349 | 38% | 13 |
| 21 (19) |  | 44 Inch Chest (2010) | £31,755 | £64,136 | £368,723 | -51% | 3 |
| 22 (22) |  | Nowhere Boy (2009) | £24,007 | £56,145 | £1,204,857 | -26% | 6 |
| 23 (new) |  | The Princess and the Frog (2010) | £15,651 | £15,651 | £15,651 | new | 1 |
| 24 (24) |  | Fantastic Mr. Fox (2009) | £13,896 | £14,671 | £8,982,985 | -26% | 14 |
| 25 (20) |  | The Boys Are Back (2010) | £11,522 | £50,306 | £114,771 | -82% | 2 |
| 26 (new) |  | Late Autumn (2010) | £9,407 | £9,407 | £9,407 | new | 1 |
| 27 (26) |  | Glorious 39 (2009) | £3,084 | £11,520 | £281,929 | -20% | 10 |
| 28 (25) | | Mugabe and the White African (2010) | £2,061 | £5,222 | £34,164 | -66% | 4 |
| 29 (27) | | Bright Star (2009) | £1,933 | £8,466 | £1,053,020 | 23% | 12 |
| 30 (new) | | Adoration (2009) | £1,780 | £1,780 | £1,780 | new | 1 |
| 31 (new) | | Horses (2010) | £1,311 | £1,311 | £1,311 | new | 1 |
| 32 (31) | | Me and Orson Welles (2008) | £633 | £9,458 | £449,995 | -47% | 8 |
| 33 (28) |  | Nativity! (2009) | £486 | £482 | £5,178,855 | -63% | 10 |
| 34 (32) |  | The Imaginarium of Doctor Parnassus (2009) | £267 | £562 | £3,928,966 | -42% | 15 |
| 35 (34) |  | Bunny and the Bull (2009) | £262 | £1,019 | £86,794 | 13% | 9 |
| 36 (33) | | Cracks (2009) | £246 | £982 | £103,830 | -40% | 8 |
| 37 (30) |  | Harry Brown (2009) | £30 | £1,601 | £4,554,087 | -98% | 11 |