| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Clash of the Titans (2010) | £2,441,682 | £6,973,160 | £12,656,035 | -57% | 2 |
| 2 (2) |  | How to Train Your Dragon (2010) | £1,399,017 | £4,936,261 | £9,782,793 | -71% | 2 |
| 3 (3) |  | Kick-Ass (2010) | £1,191,069 | £3,119,376 | £7,001,080 | -69% | 2 |
| 4 (4) |  | Nanny Mcphee and the Big Bang (2010) | £1,180,193 | £4,754,120 | £11,906,088 | -55% | 3 |
| 5 (5) |  | Alice In Wonderland (2010) | £676,516 | £2,143,770 | £40,083,901 | -47% | 6 |
| 6 (6) |  | The Blind Side (2010) | £538,730 | £1,500,033 | £4,903,322 | -46% | 3 |
| 7 (7) |  | Remember Me (2010) | £521,757 | £1,652,575 | £2,639,885 | -47% | 2 |
| 8 (new) |  | Whip It (2010) | £353,041 | £353,041 | £353,041 | new | 1 |
| 9 (8) |  | Shutter Island (2010) | £336,725 | £878,594 | £10,038,604 | -52% | 5 |
| 10 (9) |  | The Bounty Hunter (2010) | £222,664 | £707,758 | £5,851,965 | -56% | 4 |
| 11 (new) | | Io Sono L'amore (2010) | £171,959 | £171,959 | £171,959 | new | 1 |
| 12 (new) |  | Shelter (2010) | £141,452 | £141,452 | £141,452 | new | 1 |
| 13 (10) |  | The Spy Next Door (2010) | £137,485 | £529,913 | £2,305,597 | -46% | 4 |
| 14 (new) | | The Infidel (2010) | £135,448 | £135,448 | £135,448 | new | 1 |
| 15 (new) | | Prince (2010) | £68,277 | £68,277 | £68,277 | new | 1 |