| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Sex and the City 2 (2010) | £1,489,833 | £3,766,802 | £17,418,854 | -40% | 3 |
| 2 (new) |  | Letters to Juliet (2010) | £793,425 | £793,425 | £793,425 | new | 1 |
| 3 (2) |  | StreetDance 3D (2010) | £715,317 | £1,262,926 | £10,227,673 | -37% | 4 |
| 4 (3) |  | Prince of Persia: The Sands of Time (2010) | £507,855 | £1,010,908 | £7,373,367 | -38% | 4 |
| 5 (new) |  | Brooklyn's Finest (2010) | £468,279 | £468,279 | £468,279 | new | 1 |
| 6 (4) |  | Death At a Funeral (2010) | £414,711 | £866,179 | £1,562,459 | -40% | 2 |
| 7 (6) |  | Tooth Fairy (2010) | £367,396 | £612,630 | £3,053,104 | -32% | 3 |
| 8 (5) |  | Robin Hood (2010) | £362,397 | £865,386 | £14,397,521 | -44% | 5 |
| 9 (8) |  | She's Out of My League (2010) | £175,920 | £492,782 | £893,336 | -56% | 2 |
| 10 (7) |  | 4.3.2.1 (2010) | £132,048 | £366,416 | £799,634 | -70% | 2 |
| 11 (10) |  | Space Chimps 2: Zartog Strikes Back (2010) | £122,537 | £221,951 | £1,479,081 | -45% | 3 |
| 12 (new) |  | Greenberg (2010) | £118,804 | £118,804 | £118,804 | new | 1 |
| 13 (9) |  | Iron Man 2 (2010) | £113,566 | £236,685 | £20,923,193 | -50% | 7 |
| 14 (11) | | Raajneeti (2010) | £84,230 | £195,633 | £414,416 | -62% | 2 |
| 15 (12) |  | The Killer Inside Me (2010) | £66,143 | £176,294 | £300,300 | -47% | 2 |