| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Toy Story 3 (2010) | £4,666,021 | £11,733,296 | £51,524,519 | -43% | 3 |
| 2 (new) |  | Knight and Day (2010) | £2,404,163 | £2,404,163 | £2,404,163 | new | 1 |
| 3 (4) |  | Inception (2010) | £2,259,595 | £4,919,176 | £25,719,644 | -30% | 4 |
| 4 (new) |  | Step Up 3D (2010) | £2,015,403 | £2,015,403 | £2,015,403 | new | 1 |
| 5 (new) |  | Cats & Dogs: The Revenge of Kitty Galore (2010) | £1,553,005 | £1,553,005 | £1,553,005 | new | 1 |
| 6 (2) |  | The Karate Kid (2010) | £1,411,486 | £3,683,773 | £8,566,079 | -71% | 2 |
| 7 (3) |  | The A-Team (2010) | £1,386,868 | £3,472,136 | £7,041,641 | -61% | 2 |
| 8 (5) |  | Shrek Forever After (2010) | £362,464 | £1,274,498 | £30,468,038 | -60% | 6 |
| 9 (6) |  | The Twilight Saga: Eclipse (2010) | £324,469 | £1,089,429 | £28,870,688 | -58% | 5 |
| 10 (8) | | Gainsbourg (2010) | £87,125 | £208,436 | £343,467 | -35% | 2 |
| 11 (new) | | Coco Chanel and Igor Stravinsky (2010) | £52,874 | £52,874 | £52,874 | new | 1 |
| 12 (new) | | Aisha (2010) | £52,759 | £52,759 | £52,759 | new | 1 |
| 13 (14) |  | Tooth Fairy (2010) | £32,216 | £70,277 | £3,866,018 | 14% | 10 |
| 14 (7) |  | The Rebound (2010) | £28,913 | £207,148 | £1,123,719 | -84% | 3 |
| 15 (9) |  | Predators (2010) | £23,129 | £128,115 | £5,767,854 | -79% | 5 |