| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Due Date (2010) | £1,898,324 | £3,406,790 | £5,752,879 | -19% | 2 |
| 2 (new) |  | Skyline (2010) | £1,206,207 | £1,206,207 | £1,206,207 | new | 1 |
| 3 (3) |  | Despicable Me (2010) | £1,089,160 | £1,308,532 | £18,171,850 | -8% | 5 |
| 4 (2) |  | Jackass 3D (2010) | £1,059,714 | £2,304,491 | £4,001,400 | -38% | 2 |
| 5 (4) |  | Saw: The Final Chapter (2010) | £537,953 | £1,163,845 | £7,571,925 | -50% | 3 |
| 6 (6) |  | Red (2010) | £509,973 | £814,322 | £6,368,199 | -14% | 4 |
| 7 (7) |  | The Social Network (2010) | £422,895 | £751,465 | £9,781,396 | -22% | 5 |
| 8 (5) |  | Paranormal Activity 2 (2010) | £392,009 | £730,478 | £10,606,732 | -43% | 4 |
| 9 (13) |  | Alpha and Omega (2010) | £298,311 | £321,660 | £2,639,841 | 23% | 4 |
| 10 (9) |  | Another Year (2010) | £297,309 | £558,429 | £914,055 | -16% | 2 |
| 11 (8) |  | Let Me In (2010) | £292,988 | £606,904 | £1,095,076 | -40% | 2 |
| 12 (10) |  | Burke and Hare (2010) | £196,229 | £403,389 | £2,144,104 | -41% | 3 |
| 13 (14) |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | £187,684 | £228,047 | £3,041,566 | -14% | 4 |
| 14 (12) |  | The Kids Are All Right (2010) | £161,374 | £330,109 | £1,311,366 | -35% | 3 |
| 15 (new) |  | You Again (2010) | £145,034 | £145,034 | £145,034 | new | 1 |
| 16 (new) | | My Afternoons With Marguerite (2010) | £43,607 | £43,607 | £43,607 | new | 1 |
| 17 (16) |  | Made In Dagenham (2010) | £33,788 | £106,718 | £3,556,947 | -7% | 7 |
| 18 (new) |  | We Are What We Are (2010) | £30,596 | £30,596 | £30,596 | new | 1 |
| 19 (17) | | Africa United (2010) | £20,489 | £32,515 | £642,426 | -33% | 4 |
| 20 (18) | | The Illusionist (2010) | £5,673 | £10,292 | £893,302 | 15% | 13 |
| 21 (19) |  | Mr. Nice (2010) | £2,747 | £8,732 | £756,054 | -38% | 6 |
| 22 (21) | | The Arbor (2010) | £1,543 | £3,953 | £53,173 | -20% | 4 |
| 23 (24) | | Over Your Cities Grass Will Grow (2010) | £1,158 | £1,158 | £10,889 | 89% | 5 |
| 24 (23) |  | Soulboy (2010) | £532 | £3,169 | £86,956 | 0% | 9 |
| 25 (20) |  | Tamara Drewe (2010) | £224 | £2,292 | £2,565,139 | -90% | 10 |
| 26 (new) | | Aftershock (2010) | £187 | £187 | £187 | new | 1 |
| 27 (new) |  | Brilliantlove (2010) | £63 | £63 | £63 | new | 1 |