| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Trolls (2016) | £5,440,878 | £5,440,878 | £5,440,878 | new | 1 |
| 2 (new) |  | Jack Reacher Never Go Back (2016) | £2,688,561 | £2,688,561 | £2,688,561 | new | 1 |
| 3 (1) |  | The Girl On the Train (2016) | £1,996,858 | £4,077,361 | £17,732,005 | -41% | 3 |
| 4 (2) |  | Inferno (2016) | £1,297,969 | £2,785,203 | £5,755,229 | -56% | 2 |
| 5 (5) |  | Bridget Jones's Baby (2016) | £1,123,971 | £2,539,623 | £44,531,175 | -40% | 6 |
| 6 (new) |  | Ouija: Origin of Evil (2016) | £779,626 | £779,626 | £779,626 | new | 1 |
| 7 (6) |  | Miss Peregrines Home For Peculiar Children (2016) | £736,177 | £1,265,040 | £10,028,475 | -44% | 4 |
| 8 (3) |  | Storks (2016) | £668,760 | £1,178,188 | £3,425,226 | -70% | 2 |
| 9 (new) |  | I, Daniel Blake (2016) | £444,800 | £444,800 | £444,800 | new | 1 |
| 10 (new) |  | Keeping Up With the Joneses (2016) | £271,306 | £271,306 | £271,306 | new | 1 |
| 11 (new) |  | Don Giovanni: Met Opera 2016 (2016) | £254,469 | £254,469 | £254,469 | new | 1 |
| 12 (7) |  | Deepwater Horizon (2016) | £148,110 | £420,518 | £5,272,747 | -68% | 4 |
| 13 (12) |  | The Secret Life of Pets (2016) | £104,807 | £122,455 | £35,438,549 | 7% | 13 |
| 14 (9) |  | Finding Dory (2016) | £79,966 | £121,029 | £42,372,389 | -57% | 13 |
| 15 (15) |  | The BFG (2016) | £76,541 | £100,886 | £30,233,755 | 10% | 14 |
| 16 (new) | | Queen of Katwe (2016) | £73,754 | £73,754 | £73,754 | new | 1 |
| 17 (10) |  | American Honey (2016) | £67,438 | £137,397 | £312,780 | -62% | 2 |
| 18 (11) | | My Scientology Movie (2016) | £54,686 | £109,387 | £879,628 | -55% | 3 |
| 19 (17) | | War On Everyone (2016) | £32,678 | £59,618 | £388,742 | -6% | 3 |
| 20 (re) | | Cosi Fan Tutte Royal Opera London 2016/17 (2016) | £24,435 | £24,435 | £342,331 | re | 1 |
| 21 (20) |  | The Beatles: Eight Days a Week - The Touring Years (2016) | £23,385 | £40,935 | £1,062,308 | 51% | 6 |
| 22 (new) | | White Island (2016) | £19,327 | £19,327 | £19,327 | new | 1 |
| 23 (new) | | Littlescreen (2016) | £17,575 | £17,575 | £17,575 | new | 1 |
| 24 (16) |  | Supersonic (2016) | £15,797 | £45,348 | £712,939 | -60% | 3 |
| 25 (new) |  | The Third Party (2016) | £8,440 | £8,440 | £8,440 | new | 1 |
| 26 (28) |  | Swallows and Amazons (2016) | £7,396 | £16,485 | £3,037,922 | 37% | 10 |
| 27 (26) |  | The Infiltrator (2016) | £6,025 | £13,126 | £1,069,933 | -2% | 6 |
| 28 (30) |  | Jason Bourne (2016) | £5,700 | £13,061 | £23,125,398 | 57% | 13 |
| 29 (new) |  | 31st October (2016) | £5,674 | £5,674 | £5,674 | new | 1 |
| 30 (27) |  | Anthropoid (2016) | £5,257 | £12,524 | £784,629 | -11% | 7 |
| 31 (21) |  | Brotherhood (2016) | £4,237 | £9,549 | £3,690,022 | -62% | 8 |
| 32 (new) | | Sonita (2016) | £3,883 | £3,883 | £3,883 | new | 1 |
| 33 (38) |  | Bobby Sands 66 Days (2016) | £3,665 | £2,965 | £241,323 | 80% | 12 |
| 34 (new) |  | Ikimizin Yerine (2016) | £2,958 | £2,958 | £2,958 | new | 1 |
| 35 (22) |  | The Girl With All the Gifts (2016) | £2,932 | £12,124 | £1,063,882 | -74% | 5 |
| 36 (29) | | Under the Shadow (2016) | £2,706 | £5,233 | £64,871 | -35% | 4 |
| 37 (new) | | Desi Munde (2016) | £2,354 | £2,354 | £2,354 | new | 1 |
| 38 (new) | | In Pursuit of Silence (2016) | £1,981 | £1,981 | £1,981 | new | 1 |
| 39 (new) |  | Visaranai (2016) | £1,589 | £1,589 | £1,589 | new | 1 |
| 40 (4) |  | Miss Saigon 25th Anniversary Performance (2016) | £1,475 | £5,457 | £2,038,488 | -100% | 2 |
| 41 (36) | | King Lear: RSC Live 2016 (2016) | £1,438 | £6,080 | £411,547 | 4% | 2 |
| 42 (new) | | Lakeeran (2016) | £1,050 | £1,050 | £1,050 | new | 1 |
| 43 (re) |  | Branagh Theatre Live: Romeo and Juliet 2016 (2016) | £982 | £982 | £822,839 | re | 8 |
| 44 (new) | | Phantom Boy (2016) | £912 | £912 | £912 | new | 1 |
| 45 (new) | | Premam (2015) | £855 | £855 | £855 | new | 2 |
| 46 (new) |  | Before the Flood (2016) | £808 | £808 | £808 | new | 1 |
| 47 (31) | | The Greasy Strangler (2016) | £787 | £2,826 | £15,478 | -67% | 3 |
| 48 (re) | | Cymbeline: RSC Live 2016 (2016) | £670 | £670 | £231,297 | re | 3 |
| 49 (re) | | Matthew Bourne's the Car Man 2015 (2016) | £636 | £636 | £91,470 | re | 9 |
| 50 (32) | | The Deep Blue Sea: NT Live 2016 (2016) | £571 | £571 | £718,097 | -74% | 7 |
| 51 (re) | | Light Years (2016) | £308 | £308 | £2,089 | re | 2 |
| 52 (41) | | Still Loved (2016) | £148 | £2,658 | £6,406 | -41% | 2 |
| 53 (re) |  | Sour Grapes (2016) | £142 | £142 | £10,085 | re | 4 |
| 54 (re) |  | The Childhood of a Leader (2016) | £32 | £32 | £161,598 | re | 7 |