| Title | Weekend | Week | Total | % Change | Total Weeks | ||
| 1 (new) | ![]() | West Side Story (2021) | £1,297,786 | £1,297,786 | £1,297,786 | new | 1 |
| 2 (new) | ![]() | Clifford the Big Red Dog (2021) | £1,293,354 | £1,293,354 | £1,293,354 | new | 1 |
| 3 (1) | ![]() | House of Gucci (2021) | £779,973 | £1,756,615 | £7,340,675 | -48% | 3 |
| 4 (2) | ![]() | Encanto (2021) | £635,387 | £908,877 | £4,217,850 | -50% | 3 |
| 5 (3) | ![]() | Ghostbusters: Afterlife (2021) | £585,505 | £938,324 | £10,130,382 | -45% | 4 |
| 6 (5) | ![]() | Eternals (2021) | £152,524 | £301,580 | £14,768,694 | -52% | 6 |
| 7 (re) | ![]() | Home Alone (1990) Rerelease | £122,999 | £122,999 | £310,492 | re | 33 |
| 8 (6) | ![]() | No Time To Die (2021) | £118,751 | £296,226 | £96,327,994 | -56% | 11 |
| 9 (14) | ![]() | Elf (2003) Rerelease | £118,473 | £140,649 | £251,685 | 6% | 19 |
| 10 (12) | ![]() | A Boy Called Christmas (2021) | £112,036 | £160,878 | £453,836 | -16% | 3 |
| 11 (8) | ![]() | Resident Evil: Welcome to Raccoon City (2021) | £106,521 | £255,612 | £508,811 | -58% | 2 |
| 12 (7) | Boxing Day (2021) | £103,365 | £264,580 | £529,843 | -61% | 2 | |
| 13 (9) | ![]() | Dune (2021) | £94,537 | £259,670 | £21,701,533 | -61% | 8 |
| 14 (new) | ![]() | The Nutcracker: Bolshoi Ballet 2021 (2021) | £89,705 | £89,705 | £89,705 | new | 1 |
| 15 (new) | ![]() | Sword Art Online Progressive - Aria of a Starless Night (2021) | £64,612 | £64,612 | £64,612 | new | 1 |