North American Weekend Box Office
US Box Office 31st March, 2006
| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Ice Age: The Meltdown (2006) | $68,033,544 | $68,033,544 | $68,033,544 | new | 1 |
| 2 (1) |  | Inside Man (2006) | $15,437,760 | $23,553,110 | $52,508,055 | -47% | 2 |
| 3 (new) |  | ATL (2006) | $11,554,404 | $11,554,404 | $11,554,404 | new | 1 |
| 4 (4) |  | Failure to Launch (2006) | $6,463,434 | $9,550,895 | $73,088,790 | -38% | 4 |
| 5 (2) |  | V For Vendetta (2006) | $6,295,358 | $10,453,490 | $56,659,439 | -49% | 3 |
| 6 (3) |  | Stay Alive (2006) | $4,506,719 | $6,554,208 | $17,280,614 | -58% | 2 |
| 7 (6) |  | She's the Man (2006) | $4,429,426 | $6,278,535 | $26,622,732 | -39% | 3 |
| 8 (new) |  | Slither (2006) | $3,880,270 | $3,880,270 | $3,880,270 | new | 1 |
| 9 (5) |  | The Shaggy Dog (2006) | $3,242,414 | $5,731,013 | $53,554,291 | -64% | 4 |
| 10 (new) |  | Basic Instinct 2 (2006) | $3,201,420 | $3,201,420 | $3,201,420 | new | 1 |
| 11 (7) | | Larry the Cable Guy: Health Inspector (2006) | $3,159,370 | $4,536,599 | $11,459,366 | -54% | 2 |
| 12 (8) |  | The Hills Have Eyes (2006) | $1,887,636 | $3,286,038 | $39,003,204 | -57% | 4 |
| 13 (15) |  | Thank You For Smoking (2006) | $1,606,328 | $1,967,374 | $3,349,398 | 38% | 3 |
| 14 (9) |  | Eight Below (2006) | $967,928 | $2,034,367 | $79,172,307 | -64% | 7 |
| 15 (10) |  | 16 Blocks (2006) | $707,401 | $1,522,439 | $35,526,665 | -67% | 5 |