| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Clash of the Titans (2010) | $26,633,209 | $46,336,414 | $110,226,524 | -57% | 2 |
| 2 (new) |  | Date Night (2010) | $25,207,599 | $25,207,599 | $25,207,599 | new | 1 |
| 3 (3) |  | How to Train Your Dragon (2010) | $24,863,535 | $41,268,522 | $133,404,438 | -14% | 2 |
| 4 (2) |  | Why Did I Get Married Too? (2010) | $11,017,379 | $19,247,502 | $48,537,039 | -62% | 2 |
| 5 (4) |  | The Last Song (2010) | $9,832,326 | $16,860,155 | $42,255,196 | -39% | 2 |
| 6 (6) |  | Hot Tub Time Machine (2010) | $5,431,021 | $9,059,436 | $36,969,649 | -33% | 2 |
| 7 (5) |  | Alice In Wonderland (2010) | $5,301,730 | $9,275,765 | $319,009,518 | -35% | 2 |
| 8 (7) |  | The Bounty Hunter (2010) | $4,215,156 | $7,063,169 | $55,916,622 | -31% | 2 |
| 9 (8) |  | Diary of a Wimpy Kid (2010) | $3,979,641 | $7,623,021 | $53,636,368 | -25% | 2 |
| 10 (new) | | Letters to God (2010) | $1,088,873 | $1,088,873 | $1,088,873 | new | 1 |
| 11 (10) |  | Shutter Island (2010) | $885,288 | $1,560,544 | $125,001,481 | -41% | 4 |
| 12 (13) |  | Avatar (2009) | $844,651 | $1,356,295 | $743,688,973 | -14% | 12 |
| 13 (12) |  | The Ghost (2010) | $822,351 | $1,277,142 | $12,293,735 | -27% | 2 |
| 14 (9) |  | She's Out of My League (2010) | $645,893 | $1,409,893 | $30,122,867 | -57% | 2 |
| 15 (19) |  | The Girl With the Dragon Tattoo (2010) | $554,661 | $744,717 | $2,183,555 | 18% | 2 |
| 16 (11) |  | Green Zone (2010) | $534,180 | $1,099,625 | $34,218,045 | -57% | 2 |
| 17 (29) | | The Runaways (2010) | $469,260 | $561,273 | $2,517,227 | 65% | 2 |
| 18 (15) |  | Greenberg (2010) | $420,938 | $649,735 | $2,943,653 | -42% | 2 |
| 19 (14) |  | Our Family Wedding (2010) | $386,291 | $758,032 | $19,360,257 | -53% | 2 |
| 20 (20) |  | Hubble 3D (2010) | $354,191 | $797,525 | $2,764,998 | -19% | 2 |
| 21 (21) |  | Percy Jackson and the Olympians: The Lightning Thief (2010) | $288,963 | $464,032 | $87,159,279 | -11% | 5 |
| 22 (22) |  | Crazy Heart (2009) | $277,319 | $424,993 | $38,774,548 | -14% | 12 |
| 23 (17) |  | Chloe (2010) | $277,273 | $521,378 | $2,318,468 | -46% | 2 |
| 24 (new) | | The Black Waters of Echos Pond () | $224,409 | $224,409 | $224,409 | new | 1 |
| 25 (32) | | City Island (2009) | $198,973 | $253,999 | $510,869 | 28% | 2 |
| 26 (27) |  | Tooth Fairy (2010) | $191,900 | $335,943 | $58,901,756 | 4% | 7 |
| 27 (16) |  | Repo Men (2010) | $165,085 | $470,925 | $13,627,180 | -71% | 2 |
| 28 (18) |  | Remember Me (2010) | $163,774 | $454,042 | $18,696,703 | -66% | 2 |
| 29 (36) |  | Valentine's Day (2010) | $154,065 | $180,726 | $110,179,965 | 46% | 5 |
| 30 (25) |  | The Blind Side (2010) | $136,403 | $247,801 | $255,740,350 | -41% | 16 |
| 31 (26) |  | The Book of Eli (2010) | $135,004 | $227,714 | $94,482,974 | -29% | 8 |
| 32 (31) |  | Dear John (2010) | $125,476 | $224,494 | $79,826,847 | -18% | 5 |
| 33 (23) |  | Cop Out (2010) | $123,937 | $197,585 | $44,244,878 | -53% | 3 |
| 34 (34) | | A Prophet (2010) | $104,671 | $169,186 | $1,684,489 | -9% | 3 |
| 35 (24) |  | The Crazies (2010) | $103,229 | $230,642 | $38,471,410 | -60% | 3 |
| 36 (30) |  | Sherlock Holmes (2009) | $99,362 | $186,224 | $208,897,390 | -40% | 11 |
| 37 (37) | | Vincere (2010) | $81,011 | $114,184 | $297,613 | -2% | 2 |
| 38 (33) |  | Alvin and the Chipmunks: The Squeakquel (2009) | $78,887 | $181,699 | $219,485,915 | -42% | 11 |
| 39 (28) |  | Brooklyn's Finest (2010) | $72,672 | $159,254 | $26,905,697 | -58% | 2 |
| 40 (35) |  | The Last Station (2010) | $71,086 | $114,648 | $6,331,254 | -37% | 8 |
| 41 (new) |  | When You're Strange (2010) | $66,833 | $66,833 | $66,833 | new | 1 |
| 42 (re) |  | After.Life (2009) | $59,946 | $59,946 | $60,069 | re | 1 |
| 43 (39) |  | Under the Sea 3D (2009) | $55,428 | $132,268 | $21,440,937 | -8% | 43 |
| 44 (38) |  | When In Rome (2010) | $53,992 | $90,640 | $32,669,555 | -31% | 6 |
| 45 (new) | | La Mission () | $49,046 | $49,046 | $49,046 | new | 1 |
| 46 (41) |  | The Secret of Kells (2009) | $46,067 | $75,935 | $262,313 | -18% | 2 |
| 47 (60) | | Mid August Lunch () | $38,596 | $44,599 | $114,333 | 66% | 2 |
| 48 (110) |  | Magnificent Desolation: Walking On the Moon (2005) | $37,674 | $92,453 | $32,631,820 | 99% | 188 |
| 49 (45) |  | The Greatest (2009) | $37,113 | $51,852 | $85,468 | 9% | 2 |
| 50 (40) |  | Mother (2009) | $34,405 | $59,891 | $375,536 | -40% | 2 |
| 51 (67) | | The Warlords (2008) | $30,103 | $34,470 | $44,543 | 67% | 2 |
| 52 (46) |  | The White Ribbon (2009) | $29,623 | $39,870 | $2,116,924 | -11% | 10 |
| 53 (42) | | Dolphins and Whales 3D Tribes of the Ocean () | $29,343 | $44,146 | $7,633,137 | -41% | 83 |
| 54 (new) | | The Human Experience () | $27,170 | $27,170 | $27,170 | new | 1 |
| 55 (62) |  | The Imaginarium of Doctor Parnassus (2009) | $26,598 | $33,858 | $7,638,319 | 55% | 11 |
| 56 (49) | | Broken Embraces (2009) | $23,533 | $47,324 | $4,839,627 | -15% | 16 |
| 57 (50) |  | The Young Victoria (2009) | $23,070 | $52,562 | $10,913,190 | -14% | 12 |
| 58 (48) |  | A Single Man (2010) | $21,064 | $39,485 | $9,138,153 | -24% | 13 |
| 59 (51) | | North Face () | $20,240 | $32,168 | $533,116 | -12% | 6 |
| 60 (43) | | The Art of the Steal () | $19,402 | $39,405 | $405,851 | -50% | 3 |
| 61 (52) | | The Most Dangerous Man In America Daniel Ellsberg and the Pentagon Papers () | $18,582 | $26,205 | $351,577 | -18% | 6 |
| 62 (new) |  | The Square (2008) | $17,092 | $17,092 | $17,092 | new | 1 |
| 63 (57) | | Breaking Upwards () | $14,894 | $21,599 | $37,066 | -4% | 2 |
| 64 (47) | | The Yellow Handkerchief (2008) | $14,660 | $25,574 | $255,124 | -50% | 3 |
| 65 (53) | | Ajami (2010) | $14,384 | $20,795 | $489,499 | -22% | 5 |
| 66 (61) | | Formosa Betrayed () | $14,166 | $19,729 | $201,553 | 14% | 3 |
| 67 (55) |  | Deep Sea 3D (2006) | $10,931 | $23,669 | $43,136,400 | -37% | 143 |
| 68 (new) | | Everyone Else () | $10,810 | $10,810 | $10,810 | new | 1 |
| 69 (108) | | Ca$h () | $10,778 | $11,335 | $38,659 | 96% | 2 |
| 70 (86) | | The Eclipse (2009) | $10,109 | $11,861 | $35,128 | 74% | 2 |
| 71 (69) |  | Space Station 3D (2002) | $9,309 | $18,790 | $81,920,314 | 9% | 352 |
| 72 (new) | | 2012 Time For Change () | $9,009 | $9,009 | $9,009 | new | 1 |
| 73 (56) |  | An Education (2009) | $8,758 | $12,544 | $12,555,564 | -47% | 20 |
| 74 (85) | | Terribly Happy () | $8,409 | $10,087 | $120,944 | 60% | 5 |
| 75 (new) | | The Cremaster Cycle () | $7,982 | $7,982 | $7,982 | new | 33 |
| 76 (64) | | Sea Monsters a Prehistoric Adventure () | $7,622 | $14,479 | $23,075,149 | -31% | 103 |
| 77 (63) | | Sweetgrass () | $6,827 | $11,506 | $96,715 | -40% | 7 |
| 78 (71) | | Fish Tank (2009) | $6,627 | $11,696 | $345,840 | -18% | 8 |
| 79 (81) | | That Evening Sun (2009) | $6,425 | $9,768 | $246,091 | 37% | 15 |
| 80 (58) | | Waking Sleeping Beauty () | $6,110 | $13,559 | $74,555 | -60% | 2 |
| 81 (73) |  | The Girl On the Train (2010) | $5,561 | $8,067 | $151,346 | -6% | 7 |
| 82 (re) | | See What Im Saying the Deaf Entertainers Documentary () | $5,287 | $5,287 | $30,024 | re | 1 |
| 83 (re) | | Valley of the Hearts Delight (2006) | $5,164 | $5,164 | $42,365 | re | 1 |
| 84 (78) |  | The Messenger (2009) | $4,973 | $6,238 | $1,081,412 | 11% | 14 |
| 85 (82) | | Dancing Across Borders () | $4,737 | $5,575 | $17,202 | 16% | 2 |
| 86 (75) | | U2 3D (2007) | $4,508 | $6,292 | $10,304,715 | -11% | 73 |
| 87 (79) | | Creation (2009) | $4,490 | $7,055 | $306,809 | 2% | 7 |
| 88 (72) |  | My Name Is Khan (2010) | $3,964 | $6,377 | $4,009,975 | -48% | 5 |
| 89 (77) | | Bluebeard (1972) | $3,606 | $7,226 | $25,829 | -22% | 2 |
| 90 (84) | | Red Riding the Year of Our Lord 1974 () | $3,474 | $5,711 | $131,715 | -8% | 5 |
| 91 (91) | | The Oscar Nominated Short Films 2010 Live Action () | $2,698 | $3,430 | $1,007,234 | 22% | 4 |
| 92 (88) | | Lbs () | $2,691 | $4,569 | $21,445 | 15% | 2 |
| 93 (70) | | Breath Made Visible Anna Halprin () | $2,390 | $6,547 | $14,972 | -72% | 2 |
| 94 (90) | | House () | $2,270 | $2,664 | $98,837 | 3% | 2 |
| 95 (re) | | Ran (1985) | $2,150 | $2,150 | $59,814 | re | 3 |
| 96 (93) | | The Red Baron () | $2,007 | $2,791 | $36,569 | 18% | 2 |
| 97 (59) | | The Secrets of Jonathan Sperry () | $1,905 | $13,625 | $1,345,015 | -86% | 22 |
| 98 (89) |  | A Town Called Panic (2009) | $1,836 | $2,774 | $138,208 | -20% | 12 |
| 99 (105) | | 35 Shots of Rum (2009) | $1,827 | $1,827 | $168,551 | 71% | 23 |
| 100 (80) | | The Sun () | $1,603 | $3,563 | $76,357 | -63% | 12 |
| 101 (94) | | Preachers Kid () | $1,311 | $4,245 | $514,522 | -11% | 6 |
| 102 (76) | | Toe to Toe () | $1,237 | $3,097 | $19,996 | -74% | 3 |
| 103 (83) | | The Exploding Girl () | $1,105 | $3,552 | $22,223 | -72% | 2 |
| 104 (74) | | The Thorn In the Heart () | $1,090 | $1,821 | $6,994 | -79% | 2 |
| 105 (99) | | October Country () | $1,080 | $2,019 | $18,156 | -14% | 4 |
| 106 (102) | | Dreamkiller () | $862 | $922 | $9,295 | -8% | 4 |
| 107 (68) |  | Don Mckay (2009) | $750 | $4,266 | $13,185 | -92% | 2 |
| 108 (re) | | Fashion Victim () | $702 | $702 | $3,024 | re | 3 |
| 109 (re) | | Misconceptions (2008) | $561 | $561 | $6,793 | re | 3 |
| 110 (re) | | Killing Kasztner () | $531 | $531 | $86,310 | re | 16 |
| 111 (re) | | Watercolors () | $486 | $486 | $5,964 | re | 3 |
| 112 (103) | | The Trouble With Terkel () | $350 | $1,314 | $7,064 | -53% | 2 |
| 113 (111) |  | Small Change (1976) | $304 | $431 | $24,650 | 5% | 9 |
| 114 (re) | | Off and Running () | $228 | $228 | $16,522 | re | 4 |
| 115 (101) | | Prodigal Sons () | $60 | $1,368 | $62,751 | -95% | 3 |